Session Overview |
Thursday, May 23 |
13:30 |
Biodegradable Iron for Scaffold Applications: An interdisciplinary approach
* Joseph Buhagiar, University of Malta , Malta Christabelle Tonna, University of Malta Maurice Grech, University of Malta Arif Rochman, University of Malta Luke Saliba, Mater Dei Hospital Keith Sammut, Mater Dei Hospital Ray Gatt, Mater Dei Hospital Ryan Giordmaina, Mater Dei Hospital Pierre Schembri-Wismayer, University of Malta Iron-based biodegradable metal bone graft substitutes have emerged as a particularly attractive option for the filling of bone defects. In this work we will describe a novel powder metallurgy processing method (WIPO PCT Patent WO2021255195A1) to produce metal scaffolds and foams. In extension we will highlight the issues related to the high vapour pressure and high temperature reactivity of Mn. In addition, in this work we present our long-term corrosion in vitro studies on an Fe35Mn powder metallurgy alloy and compare them with in vivo work. Our results demonstrate how considerable the gap between the in vivo and in vitro findings, really is. Finally, we will emphasize on the importance of an interdisciplinary approach and our future research plans on biodegradable alloys. |
14:00 |
Corrosion fatigue of additively manufactured iron-manganese scaffolds
* Niko Eka Putra, Delft University of Technology, Netherlands Vahid Moosabeiki, Delft University of Technology, Netherlands Marius A. Leeflang, Delft University of Technology, Netherlands Jie Zhou, Delft University of Technology, Netherlands Iulian Apachitei, Delft University of Technology, Netherlands Amir A. Zadpoor, Delft University of Technology, Netherlands Additively manufactured (AM) biodegradable iron-manganese (FeMn) alloy scaffolds have recently been emerged as promising bone-substituting biomaterials. However, the corrosion fatigue behavior of such materials in physiologically relevant environment is unknown, particularly those made by extrusion-based AM. In this study, we present the first results on the corrosion fatigue behavior of the extrusion-based AM FeMn alloy scaffolds (with 35 wt% Mn) under cyclic loading in air, as well as in the revised simulation body fluid (r-SBF), supplemented with the micro-computed tomography (µCT) analysis. The results showed that the extrusion-based AM porous FeMn scaffolds in r-SBF and in air could tolerate up to 60% of their yield strength and 90% of their yield strength, respectively, for 3 million cycles. No observable crack formation occurred in the specimens tested in air, even when they were loaded up to 90% of their yield strength. However, µCT images revealed significant signs of crack formation in the specimens tested in the r-SBF and subjected to loads exceeding 60% of their yield strength, with cracks initiating on the periphery of the specimens and propagating toward the internal struts. The highly encouraging corrosion-fatigue performance of the scaffolds warrants further research toward clinical adoption for temporary bone substitution. |
14:15 |
Drug-eluting biodegradable metals: high strength and prolonged drug release
* Aliya Sharipova, Fraunhofer IKTS, Germany Olga Bakina, Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Science, Russia Aleksandr Lozhkomoev, Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Science, Russia Marat Lerner, Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Science, Russia Alejandro Sosnik, Technion - Israel Institute of Technology, Israel This work reports on the fabrication and characterization of vancomycin (VH)-loaded biodegradable metals using a cold sintering method. On example of iron (Fe), we investigate the mechanical and degradation properties of VH-free and VH-loaded metals. Results show very high mechanical strength of drug-eluting Fe (up to 580 MPa under compression) accompanied by initial drug release during 9 days and extended drug release by matrix degradation. Our results show the potential of biodegradable metals for local drug delivery in bone healing. |
14:30 |
Plasma immersion ion implantation affects surface properties of Fe-Mn-based alloys for vascular applications
Leticia Marin de Andrade, Laboratory of Biomaterials & Bioengineering, Dpt Min-Met-Mat. Engineering, CR-CHU de Quebec, Laval University, Canada Pascale Chevallier, Laboratory of Biomaterials & Bioengineering, Dpt Min-Met-Mat. Engineering, CR-CHU de Quebec, Laval University, Canada Francesco Copes, Laboratory of Biomaterials & Bioengineering, Dpt Min-Met-Mat. Engineering, CR-CHU de Quebec, Laval University, Canada Carlo Paternoster, Laboratory of Biomaterials & Bioengineering, Dpt Min-Met-Mat. Engineering, CR-CHU de Quebec, Laval University, Canada Diego Mantovani, Laboratory of Biomaterials & Bioengineering, Dpt Min-Met-Mat. Engineering, CR-CHU de Quebec, Laval University, Canada * Maria Elena Lombardo, Laboratory of Biomaterials and Bioengineering, Dep. Min-Met-Mat. Engineering, CR-CHU de Québec, Laval University, Canada Current research on biodegradable iron-based alloys aims at regulating the material degradation rate, as well as its biological performances, including hemocompatibility and cytocompatibility. A fine-tuning of the surface roughness, morphology and chemical composition of the alloy can improve the functional response on the material. To this aim, plasma immersion ion implantation (PIII), was proposed, to selectively enable the surface properties of the metallic materials without affecting those of the bulk. In this work, the influence of treatment time (15, 60 and 120 min) and gas composition (O2, N2 and CH4) on the surface properties of an electropolished (EP) Fe-Mn-C based biodegradable alloy, here Fe-13Mn-1.2C, were investigated. Results clearly show that implantation gas and treatment time have an impact on topography and morphology, assessed by SEM and AFM, as well as on the chemical composition of the surface, determined by XPS analyses. The wettability behavior, related to both the chemical composition and morphology, decreased compared to the EP sample. In addition, longer plasma exposure resulted in deeper species penetration into the alloy, as demonstrated by XPS depth profiling. Besides samples treated with O2 and CH4 were found hemocompatible. Therefore, PIII implantation appears a versatile solution for fine-tuning the surface topography, composition and biological properties, making it therefore promising for the development of metallic biodegradable vascular implants. |
14:45 |
Biodegradable nanopowder fabrication by pulsed laser-triggered process for biomedical applications
* Seung-Hoon Um, Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering & CHU de Quebec Research Centre, Regenerativ, Canada Carlo Paternoster, Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering & CHU de Quebec Research Centre, Regenerativ Francesco Copes, Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering & CHU de Quebec Research Centre, Regenerativ Pascale Chevallier, Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering & CHU de Quebec Research Centre, Regenerativ Hyung Seop Han, Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST) Diego Mantovani, Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering & CHU de Quebec Research Centre, Regenerativ Biodegradable metals are increasingly finding applications in the medical field. Especially biodegradable alloys with Fe (iron) as the primary component are attracting attention in the biodegradable medical field due to their high mechanical strength and corrosion rate characteristics. Nonetheless, there is a significant shortage of research in the production of nano-sized Fe-based biodegradable metal powders, which are crucial for enhancing the resolution of metal 3D printers and for drug development with skin penetration methods. In this research, we developed the fabrication process of nano-sized Fe-based biodegradable metal powder through pulse laser technology and assessed the potential for bio-medical applications. |
15:00 |
Iron Nanoparticle-Coated Fabric: Fighting COVID-19 with Skin-Safe Shield
Jamilly Salustiano Ferre Constantino, Universidade Federal do Ceara, Brazil * Rodrigo Silveira Vieir, Universidade Federal do Ceara, Brazil This study introduces hybrid coating systems combining biopolymers and iron oxide nanoparticles (IONPs) to combat SARS-CoV-2. These coatings exhibit rapid antiviral activity, effectively neutralizing the virus within minutes. Particularly promising is the IONPs/N-succinyl chitosan system, demonstrating minimal iron leaching and enhanced virucidal efficacy. These findings suggest a crucial role for these coatings in enhancing protective equipment safety and preventing future pandemics. Biocompatibility assessments reveal no adverse effects on cellular viability, highlighting the safety of deploying such coatings. In conclusion, this research underscores the potential of hybrid coatings as effective tools against SARS-CoV-2, offering a versatile and sustainable approach to virus control and public health enhancement. |