Biophotonics - 3Virtual room: INO - 2
|Wednesday, May 27|
BP-3-27-1 / Amyloid Deposits in the Retina of the Human Eye are Biomarkers of Two Different Diseases
* Peter Neathway, University of Waterloo, Canada
Yifan Ding, University of Waterloo
Monika Kitor, University of Waterloo
Laura Emptage, University of Waterloo
Veronica Hirsch-Reinshagen, University of British Columbia
Ging-Yuek Robin Hsiung, University of British Columbia Hospital
Ian Mackenzie, University of British Columbia
Melanie Campbell, University of Waterloo
Retinal amyloid deposits were studied ex vivo in three-dimensions using confocal scanning laser microscopy. Some deposits were found in association with blood vessels with morphologies that resembled those reported in association with cerebral amyloid angiopathy (CAA). Others associated with neural cell layers, previously imaged in atomic force microscopy, had morphologies similar to those typically reported in the brain in Alzheimer’s disease. Deposits associated with neural cell layers, imaged here, differed from the previous two morphologies.
BP-3-27-2 / Label-Free Phenotyping of Human Cells with Multimodal Digital Holographic Microscopy
* Prof. Erik Bélanger, Centre de recherche CERVO, Université Laval, Canada
Céline Larivière-Loiselle, Centre de recherche CERVO, Université Laval
Émile Rioux-Pellerin, Centre de recherche CERVO, Université Laval
Sara Mattar, Centre de recherche CERVO, Université Laval
Prof. Pierre Marquet, Centre de recherche CERVO, Université Laval
We demonstrate label-free cell phenotyping by measuring various biophysical parameters with a multimodal imaging system based on digital holographic microscopy. Different developments allowing the monitoring, in various paradigms, of specific biophysical parameters are presented.
BP-3-27-3 / Optimal pupil size in older adults for retinal imaging
* Julia Zangoulos, University of Waterloo, Canada
Melanie Campbell, University of Waterloo
An eye model incorporating monochromatic aberrations of older eyes was designed in CodeV to determine optimal imaging parameters for retinal imaging instruments targeting older individuals. The optimal pupil size for lateral resolution based on ocular aberrations of 13 subjects was found to be 3.0 mm ± 0.3 mm, providing lateral resolution of 4.1µm ± 0.6µm.
BP-3-27-4 / The Effects of Facial Electrical Stimulation on Visual Perceptions
* Faraz Sadrzadeh-Afsharazar, Ryerson University, Canada
Alexandre Douplik, Ryerson University, Canada
We study electro-stimulation of Phosphene patterns.
BP-3-27-5 / A Simple Acoustic-Based Method for Lens-to-Sample Distance Adjustment in micro-LIBS
* Hamed Abbasi, University of Basel, Switzerland
Philippe Cattin, University of Basel
Azhar Zam, University of Basel
A cost-effective method employing a smartphone sensor to measure the laser-induced sound pressure level (SPL) has been introduced for lens-to-sample distance (LTSD) adjustment in micro laser-induced breakdown spectroscopy (μLIBS).
BP-3-27-6 / Design of an All-reflective Line Based Spectrometer for Optical Coherence Tomography
* Sevin Samadi, Concordia university, Canada
Sivakumar Narayanswamy, Concordia university
Javad Dargahi, Concordia university
Optical coherence tomography (OCT) is an interferometric technique for diagnostic medical imaging. The multidisciplinary nature of OCT is one of the reasons that there has been so many innovations in this field with more still to come. Since OCT spans a wide range of applications, there is a huge need for designing new OCT systems to cover unmet needs. The main contribution of this work is to design and optimize a new all-reflective spectrometer system compared to traditional refractive optics. In this all-reflective design, chromatic aberration is reduced significantly. Moreover, the Effective focal length of the spectrometer mirror is no longer wavelength related. In the following, the spectrometer design of our approach and its analysis will be explained and discussed. The spectrometer is used for data acquisition in spectral domain OCT. The data acquired by the spectrometer is processed by Fourier Transform. The spectrometer is made of different components like diffractive grating, collimating and focusing optics. The traditional refractive optics causes two limitations in the spectrometer system; first one is that the axial resolution drop by changing the wavelength and the second one is depth-dependent signal falls off. Traditionally custom-designed chromatic lenses are used to minimize chromatic aberration, which is expensive. To overcome these drawbacks, a reflective spectrometer design is introduced in this part. Reflective optics are not dependent on a wavelength so it improves the image quality. In This work a spectrometer is designed and optimized using ZEMAX software. The design is based on a fold mirror, grating, and a focusing mirror.
BP-3-27-7 / Morphological and vascular changes in the human conjunctiva and sclera associated with wear of novel contact lenses
* Weixiang Song, University of Waterloo, Canada
Kostadinka Bizheva, University of Waterloo
Contact lens edges can cause temporary or permanent changes in the conjunctival and scleral morphology and blood vasculature. Here we utilize high-speed UHR-OCT to evaluate those changes for different types of soft contact lenses.