Biophotonics - 4Virtual room: Optonique - 3
|Thursday, May 28|
BP-4-28-1 / Improving the patient cancer experience: Multispectral (White Light/Autofluorescence/Raman) Needle Endoscopy for cancer diagnostics in breast and thyroid
* Alexandra Easson, University Health Network
Aditya Pandya, Ryerson University
Jesse Pasternak, University Health Network
Nuaira Mohammed, Ryerson University
Alexandre Douplik, Ryerson University, Canada
We develop a facility for biopsy imaging guidance and treatment monitoring for breast and thyroid cancer using endoscopy through hollow superfine acupuncture size needle significantly reducing tissue destruction, pain and bleeding. Such an endoscope will employ advanced optical techniques such as Fluorescence and Raman spectroscopy to provide highly accurate allowing a small invasive examination at the time of consultation, early diagnostics, reducing number of biopsies and surgery.
BP-4-28-2 / The impact of transit time on a microflow cytometer for particle classification
* Yushan Zhang, McMaster University, Canada
Chang-qing Xu, McMaster University
Microflow cytometers and many other miniaturized microfluidic devices have shown great potential in many fields, such as, particle detection, cell sorting and classification. A reliable signal analysis method is required to improve the measurement accuracy of the emerging microfluidic devices. In this paper, a novel method is presented to analyze the signal from microspheres with different diameters based on transit time and amplitude. Experimental results show that transit time threshold plays a more important role at lower flow rate for particle differentiation and can be used to improve the performance of a microflow cytometer.
BP-4-28-3 / C-reactive protein test based on microflow cytometry for on-site clinic diagnosis
* Jianxi Qu, Mcmaster University, Canada
Yushan Zhang, Mcmaster University
Chang-qing Xu, Mcmaster University
A novel method based on microflow cytometry is proposed for on-site C-reactive protein (CRP) test. CRP concentrations ranging from 0 to 2 mg/L was measured by the proposed method. It was found that the proposed method has a high sensitivity, and can be completed within 3 minutes with an assay volume as low as 10 uL.
BP-4-28-4 / Highly reproducible LSPR-nanoprobe manufacturing process
* Angel Ortega, University of Basque Country, Spain
Joseba Zubia, University of Basque Country
Joel Villatoro, University of Basque Country / Ikerbasque, Basque Foundation for Science
In this work, a LSPR-nanoprobe manufacturing process based on deposition of AuNPs onto an optical fiber facet is shown. The immobilization is carried out chemically, but it is controlled in real time, achieving a reproducibility ratio of 85%. The main application of these nanoprobes is the biochemical sensing. In addition, we compared the response of two fibers with core diameter of 105 µm and 50 µm as well.
BP-4-28-5 / Magneto-optic-plasmonics and Optical Biosensors - Potential Game Changers in Health Industry
* Conrad Rizal, Seed NanoTech International Inc., Canada
Biosensors play an important role when it comes to detecting diseases, monitoring them, and improving human health. Magneto-optic-plasmonics - a sub-field of physics that merges optics, magnetics and plasmonics is an emerging new field and has huge potential to develop many new types of technologies, including optical biosensors. We have shown earlier that the sensors based on magneto-optic-plasmonic principle are almost over two order sensitive and show higher detection limits over conventional surface plasmon resonance-based sensors. The improved sensitivity and detection limit shown by these sensors allow industries to develop locally more robust bio-sensing instruments at an affordable cost. These instruments can make large impacts on early diseases detection and thus the day-to-day lives of the people who would use them. Due to the high sensitivity and detection limit, these devices are expected to play a significant role in health care industry in the days to come. Since not all the biosensors are equally created, so it is important to understand which technologies are more effective. In this talk I will discuss about magneto-optic-plasmonics principle, sensors based on them, pros and cons compared to the traditional SPR sensors, discuss the current status of it and future prospects .
BP-4-28-6 / 3D Tissue Mimicking Phantoms with Patterned Oxygenation States of Hemoglobin for Photoacoustic Applications
* Aditya Pandya, Ryerson University, Canada
Harshad Karia, Ryerson University
Alexandre Douplik, Ryerson University
Aluminium sulphonated phthalocyanine (AlPs) photosensitiser mixed with Hemoglobin (Hb) was used to create patterned oxygenation states of Hb in tissue mimicking gelatin phantoms. Temporal study of Hb conversion and an oxygenation patterned phantom is presented.
BP-4-28-7 / A Photonic Crystal Slab-based Ultrasonic Sensor
* Eric Zhu, University of Toronto, Canada
Maria Charles, University of Toronto
Cory Rewcastle, University of Toronto
Raanan Gad, University of Toronto
Li Qian, University of Toronto
Ofer Levi, University of Toronto
The refractive-index (RI)-sensing capabilities of a photonic crystal slab (PCS), coupled with the photoelastic effect in a polymer overlayer, are exploited to measure ultrasonic signals in water.